John R. Yates III is an American chemist and Ernest W. Hahn Professor in the Departments of Molecular Medicine and Neurobiology at The Scripps Research Institute in La Jolla, California.
[1][2][3] His work is focused on developing tools and in proteomics and he specializes in mass spectrometry.
He is best known for the development of the Sequest algorithm for automated peptide sequencing[4][5] and Multidimensional Protein Identification Technology (MudPIT)[6] and data-independent acquisition.
[7] His lab is known for its contribution to methods to identify structural changes in proteins in living cells as well as method to identify N-glycan processing and occupancy using mass spectrometry such as covalent protein painting,[8] and DeGlyPHER (Deglycosylation-dependent Glycan/Proteomic Heterogeneity Evaluation Report).
[9] His laboratory has made important contributions to understanding the biochemical mechanisms behind the failure of △F508 cystic fibrosis ion transport regulator to mature.