The distinctive large white-tiled structure occupies a prominent position on Headington Hill, on the outskirts of Oxford.

[2] Other facilities were then added to the site, including the University of Oxford's Centre for Functional Magnetic Resonance Imaging (fMRI) of the Brain.

[3] The West Wing: With the closure of the Radcliffe Infirmary and consolidation of the other hospital sites in Oxford, a further large expansion took place, the facilities for which were procured under a Private Finance Initiative contract in 2003.

[5] The Queen and The Duke of Edinburgh officially commemorated the opening of the new West Wing and Children's Hospital at a special ceremony in late November 2008 in front of patients, staff, fundraisers and supporters who had helped raise the £15 million needed to build the Children's Hospital.

[6] In 2017 the Oxford University Natural History Museum donated a model Utahraptor for the entrance to the Children's Hospital.