Sir John Salusbury (1567 – 24 July 1612) was a Welsh knight, politician and poet of the Elizabethan era.

He is notable for his opposition to the faction of Robert Devereux, 2nd Earl of Essex, and for his patronage of complex acrostic and allegorical poetry that anticipated the Metaphysical movement.

After his brother's execution, he succeeded to the estates, but the family's lands were severely reduced due to the loss of crown leases.

Salusbury became noted for his "ostentatious loyalty" to the queen, in contrast to other members of his family, who were associated with Catholic sympathies and plots against her.

The 5th Earl of Derby, his wife's brother, wrote to congratulate him for beating "that bad fellow of your name", saying that the event would be to the "advancement of your credit".

[6] His copy of Gerard's Herbal survives at Christ Church, Oxford with annotations describing plants and herbs found in Welsh gardens or growing wild around the year 1606, with some of his notes of recipes[7].

The most important work linked to Salusbury is Robert Chester's book Love's Martyr, which is dedicated to Sir John.

[citation needed] Both Parry and Chester seem to have been local Denbighshire writers who formed part of Salusbury's own circle.

Salusbury's own poetry may have been published in Parry's collection in the section entitled the "patron's pathetical posies", though this has been disputed.

[11] Salusbury also seems to have been acquainted with Ben Jonson, who may have been the person responsible for organising a group of important poets to contribute verses to supplement Chester's poems.