He was principal cellist with the Saint Louis Symphony Orchestra from 1968 to 2005 under music directors Walter Susskind, Jerzy Semkow, and Leonard Slatkin.
He is a member of the Generation Gap Piano Trio with violinist Dmitri Pogorelov and pianist Judith Lynn Stillman.
Sant’Ambrogio is founder (2003) and artistic director of the Arts for the Soul Summer Vacation Retreat in Steamboat Springs, Colorado.
Piatigorsky Award (1953), presented at Berkshire Music Festival at Tanglewood, in Lenox, Massachusetts, the summer home of the Boston Symphony Orchestra.
National Music Educators Award (1964), featuring a solo performance with Thomas Scherman's Little Orchestra Society in The Town Hall, New York City.