He claimed his first PGA Tour title on 16 July 2006 at the John Deere Classic, a one-shot victory over American J. P. Hayes.

In 2007, he was the leading Australian at the PGA Championship which was won by Tiger Woods and reached the top 50 of the Official World Golf Ranking.

[2] In March 2014, Senden won his second PGA Tour title (and first in eight years) at the Valspar Championship by one stroke over Kevin Na.

Senden played the next two seasons using a Major Medical Extension under the family crisis provision, but he was unable to meet the terms and was demoted to the Past Champions Category.

QF, R16, R32, R64 = Round in which player lost in match play "T" = Tied Note that the HSBC Champions did not become a WGC event until 2009.