After graduating from Lorain Catholic High School in 1984, he was admitted as a candidate to the Order of Friars Minor Conventual (Minorites).

He received his episcopal consecration from Archbishop Joseph Kurtz, with Bishops Armando Ochoa and Gabriel Enrique Montero Umaña serving as co-consecrators[citation needed] on May 5, 2015.

[3] In January 2019, Stowe wrote an op-ed in the Lexington Herald-Leader that criticized Nick Sandmann and other students from Covington Catholic High School for sporting apparel supporting President Donald Trump during the 2019 March for Life rally in Washington, D.C.[4] Stowe said the slogan "Make America Great Again" on their clothing: [...] supports a president who denigrates the lives of immigrants, refugees and people from countries that he describes with indecent words and haphazardly endangers with life-threatening policies.

[5][6]In March 2021, Stowe expressed support for the federal Equality Act, proposed legislation that was opposed by the U.S. Conference of Catholic Bishops.

"[7] On May 21, 2024, the Diocese of Lexington released a statement that said Stowe accepted the profession of Brother Christian Matson, as a hermit, who identifies as transgender.