Born in Houndsditch, London, he was the son of John Strype (or van Stryp) and cousin to sailor and writer Robert Knox.
A member of a Huguenot family who, in order to escape religious persecution within Brabant, had settled in East London.
He was never instituted or inducted to the living of St Mary's Church, Leyton, but in 1674 he was licensed by the Bishop of London to preach and expound the word of God, and to perform the office of priest and curate while it was vacant, and until his death he received the profits of it.
In 1711 he obtained from Archbishop Thomas Tenison the sinecure of West Tarring, Sussex, and he discharged the duties of lecturer at Hackney from 1689 until 1724.
[3] Through his friendship with Sir William Hicks, Strype obtained access to the papers of Sir Michael Hicks, secretary to Lord Burghley, from which he made extensive transcripts; he also carried on an extensive correspondence with Archbishop William Wake and Bishops Gilbert Burnet, Francis Atterbury and Nicholson.