In 1878, he came to Birmingham and after leaving school entered the Broad Street offices of Messrs. Nettlefold and Co. (later GKN).
He was also chairman of Thomas Smith's Stampings Ltd, and a director of Henry Hope and Sons Ltd for a considerable period.
In addition to his work for social reform Nettlefold was interested in charitable and philanthropic movements.
[2] Whilst living in Birmingham, Nettlefold commissioned a home for his family from the architect Joseph Lancaster Ball.
[5] In 1907 when the majority of inner city housing was of a crowded back-to-back design, Nettlefold established the garden suburb Moor Pool in Harborne to provide low density affordable housing with many interspersed green spaces, centred around a community hall.