John Thomas Deweese (June 4, 1835 – July 4, 1906) was an American politician of the Republican Party who served as a U.S. representative from North Carolina.

Born in Van Buren, Arkansas, on June 4, 1835, Deweese was educated at home, where he studied law; he was admitted to the bar in 1856 and commenced practice in Henderson, Kentucky.

DeWeese entered the Union Army on July 6, 1861, as second lieutenant of Company E, Twenty-fourth Regiment, Indiana Volunteer Infantry, and served with that command until February 15, 1862, when he resigned.

He was quickly mustered in as captain of Company F, Fourth Indiana Cavalry, on August 8, 1862, and was successively promoted to rank of colonel; he was brevetted Brigadier-General of Volunteers effective March 13, 1865.

He then switched parties and became a delegate to the Democratic National Convention in 1876, resumed the practice of law, and died in Washington, D.C., on July 4, 1906.