Coming into a scoreless tie in relief of Steve Gromek in the fifth inning of a game against the Baltimore Orioles, Tsitouris had an adventurous top half of the sixth frame, surrendering two hits and a stolen base, but emerged unscathed when Oriole baserunners Joe Durham and Dick Williams were both thrown out at home plate.

Tsitouris pitched 12⁄3 innings that day and gave up one earned run, three hits and two bases on balls, but ended up getting credit for a 2–1 victory.

[3] After the 1960 season, Tsitouris was traded to the Cincinnati Reds along with John Briggs for left-handed pitcher Joe Nuxhall.

Tsitouris made the most of it, giving up only two earned runs in 21⅓ innings and hurling a complete game, five-hit shutout against the Philadelphia Phillies on September 30.

[5] However, with his effectiveness diminishing year-by-year, Tsitouris was sent to the Triple-A Buffalo Bisons in 1966 and, despite brief trials with Cincinnati in 1967–68, spent the rest of his career in the minors.