After playing at Exeter, Weymouth, and elsewhere, with Edmund Kean, and at Swansea with John Cooper, he made his first appearance at Bath in October 1813 as Jaffier in Venice Preserv'd.
During the season he was seen as Sir Giles Overreach in A New Way to Pay Old Debts, and in the title roles of Coriolanus, and Pizarro by Richard Brinsley Sheridan.
On the transference of Thomas Talfourd's Ion from Covent Garden to the Haymarket in August 1836, he played Adrastus: on the whole, according to William Macready, a "very tiresome" performance.
Among his original characters were Eleazer in The Jewess in the season of 1835–1836, Louis XIV in Edward Bulwer-Lytton's The Duchess de la Vallière (Covent Garden, January 1837), and Pym in Robert Browning's Strafford in May.
He died on 4 October 1861 at his home in North Bank, Regent's Park, London[1][2] and is buried on the western side of Highgate Cemetery (plot no.10494).
[1][2] Upon Vandenhoff's first appearance in London, The New Monthly Magazine described him as "possessor of a tall figure, intelligent but not strongly marked features, and a voice sufficiently powerful but rather of a coarse quality".
John Westland Marston credits him with great dignity, and with thinking out happily his characters, praising highly his Coriolanus and Creon, but speaking of his Othello and Macbeth as deficient in pathos and passion.