The John W. Coffren House and Store are two historic buildings located at Croom in Prince George's County, Maryland.

This assemblage is significant for their architecture, as well as their association with the commercial history of the area and with John W. Coffren, local merchant and landowner.

The Coffren House, built in 1861, has a Greek Revival entrance and interior detail.

1853, is a utilitarian structure, designed for use as a one-room general store.

Their builder, John W. Coffren (1828-1874), who rose from ditch digger to wealthy merchant, served on the Vestry of St. Thomas Church in Croom and on the Prince George's County School Board, as well as owning much of the property in the Village of Croom.