[2][3] A right-handed pitcher, he began his professional baseball career in 1931 playing in spring training with the Chattanooga Lookouts of the Southern Association.

[13][14] Chambers made his major league debut on May 4, entering a game against the Boston Braves in the eighth inning and allowing one hit and one walk while striking out one of the five batters he faced.

[15][17] He was optioned to back to Columbus on May 21 and would remain with the club for the remainder of 1937, ending the year with a 12–7 record and 3.78 ERA.

[18][5] After the season ended, Cardinals general manager Branch Rickey told Sid Keener of the St. Louis Star-Times that he believed Chambers had the best chance of the club's pitching prospects to make the team in 1938.

[22][23] The Dodgers optioned Chambers to the Minneapolis Millers on August 12 after the club acquired Lee Rogers from the Boston Red Sox.

[1][28][29] Named the opening day starter for Chattanooga, Chambers battled more arm trouble in 1939 and was ultimately placed on the injured list before returning on May 9.

[36] He did not play organized baseball from 1942 to 1944 due to arm issues, but returned in May 1945 when he signed with the Minneapolis Millers.