[1] The musical's world premiere was on June 2, 2010 at the Loeb Drama Center of the American Repertory Theater.

[3][4] The Curse is traced to the interactions of three people: the fictional Johnny O'Brien, a hard-luck right-hander on the 1919 Red Sox; his idol, Babe Ruth; and O'Brien's love interest, Daisy Wyatt, an African American blues singer.

The show is told through flashbacks between the fourth game of the 2004 American League Championship Series and the fictional life of Johnny O'Brien.

[5] The cast featured Colin Donnell as the fictional character Johnny O'Brien, Stephanie Umoh as the fictional character Daisy Wyatt, Burke Moses as Babe Ruth, Charl Brown as Tim, and Jeff Brooks as Tom Yawkey.

[4] The creative team included direction by Diane Paulus, choreography by Peter Pucci, orchestrations by Wendy Bobbitt Cavett, costumes by Michael McDonald, sets by Scott Pask, and lighting by Donald Holder.