[1] He played in Major League Baseball as a catcher for the Chicago White Sox (1958–1959, 1965–1966), Cleveland Indians (1960–1964) and St. Louis Cardinals (1967).

[1] A four-time All-Star, Romano was considered one of the top catchers in the American League during the early 1960s before injuries prematurely ended his playing career.

The Indians' manager was former major league All-Star catcher Walker Cooper, who tutored Romano and helped to greatly improve his catching skills.

[5] Romano was called up late in the 1958 season, making his major league debut with the Chicago White Sox on September 12, at the age of 23.

[1] The White Sox' manager, Al López was also a former major league catcher who helped Romano improve his catching skills.

[5] Playing as a backup to Sherm Lollar in 1959, Romano hit .294 with 5 home runs and 25 RBIs in 53 games, as the Go-Go White Sox won their first American League Pennant in 40 years.

[1][14] Romano had another good year in 1962, hitting 13 home runs by mid-season, and was selected as a reserve catcher for the American League in the 1962 All-Star Games.

[9][21] Romano had a productive season in 1965 with the White Sox, hitting 18 home runs with a respectable .355 on-base percentage in cavernous Comiskey Park.