[1] It is located approximately halfway between Libertytown and Union Bridge along Maryland Route 75 (Green Valley Rd).
[2] The town of Johnsville was first settled by English and German immigrants in the 1740s, including the Birely and Iler families.
[6] A map of Frederick County, drawn by Isaac Bond in 1858, records the presence of a hotel, a wheelwright's shop, a blacksmith's shop, two stores, a post office, school, a physician, and two churches (Methodist Episcopal and Methodist Protestant) in Johnsville.
Historic structures along the single street through the town document its important role as a place where travelers could obtain necessary services while moving between larger population and commercial centers.
A few of the historic structures in Johnsville include the Methodist Protestant Church (today Johnsville United Methodist Church), built in 1842 and displaying intricate brickwork resulting from a later renovation; the Johnsville Schoolhouse, built in 1903; the former Methodist Episcopal Church, a frame Gothic Revival structure built in 1851; the Grove Store, a large compound structure with combined commercial and residential spaces built in 1875 in Italianate style; the Wolf House, a circa 1840 Greek Revival styled house with later Italianate porch; and the Dr. Sidewell House, a compound stone and brick structure reflecting two periods of construction (circa 1810 and 1840).