He has also written for King of the Hill, The Critic and The Office, and has served as a screenwriter or consultant for several animated and live-action movies, including Ice Age (2002), Robots (2005), and Horton Hears a Who!
Prior to joining The Simpsons, he had a brief stint at Saturday Night Live, describing his experience on a DVD commentary as "a very unhappy year."
Vitti was among the earliest writers hired for The Simpsons in 1989; he is credited as a story editor for the show's first season alongside contributing numerous scripts.
Although he would contribute occasional scripts to The Simpsons throughout the following decade - most notably "Home Sweet Homediddly-Dum-Doodily" - Vitti remained largely uninvolved with the series from the fifth to the twelfth season; he would ultimately return as a producer for seasons 13 and 15.
On the season four Simpsons episode "The Front," Jon Vitti is caricatured as a Harvard graduate who gets fired from I&S Studios for penning mediocre episodes and gets hit on the head with a name plate by his boss, Roger Meyers.