[1][2] Aspropotamitis made his professional debut on 11 March 2015 vs Melbourne City FC in a 3–2 victory for the Western Sydney Wanderers at Pirtek Stadium.

Early in the 2015–16 season Aspropotamitis got the opportunity to fill in for the experienced Alberto Aguilar who sustained an injury in the round 4 encounter v Perth Glory.

An assured display from the young centre back, coupled with the Wanderers first win of the season, lead to his selection over the following weeks.

[5] In November 2020, Aspropotamitis was selected as part of the 2020 AFC Asian Champions League squad which played out the remaining games, which were originally postponed due the COVID-19 pandemic, in Qatar.

In 2017 Aspropotamitis was part of the Australia men's national under-23 soccer team squad which competed in the 2018 AFC U-23 Championship qualification tournament.