[2] Casillas was coming off surgery from a knee injury and was only a participant in the bench press at the NFL Combine.

In Super Bowl XLIV, he was officially credited with recovering the Saints's third-quarter onside kick to start the second half en route to their 31–17 victory over the Indianapolis Colts.

However, he suffered a foot injury during the last game of the preseason, and he was placed on the injured reserve list, ending his 2010 season.

[8][9] Signed as a special teamer, Casillas emerged as a starter for the Giants midway through the 2015 season.

In 2017, Casillas started eight games before being placed on injured reserve on December 6, 2017 after battling wrist and neck injuries.