His feature directorial debut was the 2006 dramatic horror film All the Boys Love Mandy Lane, starring Amber Heard with the screenplay written by Jacob Forman.
Next, Levine directed the 2011 film 50/50 starring Seth Rogen, Joseph Gordon-Levitt and Anna Kendrick, about a young man being treated for cancer.
[6][7] It stars Nicholas Hoult as a zombie who slowly begins to return to normal, and forces a girl played by Teresa Palmer to stay with him.
In 2014, Levine directed the pilot episode of the TV series he created with Gina Matthews and Grant Scharbo, Rush, for the USA Network.
[9] In addition to writing or co-writing the screenplays for many of the feature or short films that he directed, Levine has written an episode of the TV series The Screen Junkies Show entitled "Zombie Acting Tips" (2013).
Levine produced the 2016 film Mike and Dave Need Wedding Dates, directed by Jake Szymanski and starring Zac Efron, Adam Devine, Anna Kendrick, and Aubrey Plaza.