[3][4][5] Earlier in his career, Nez served as a council delegate representing Tsah Bii' Kin, Navajo Mountain, Shonto, and Oljato Chapters.

In 2024, he won the (uncontested) Democratic nomination to represent Arizona's 2nd congressional district, becoming "the first Indigenous political candidate in Arizona to clinch a major party nomination for a congressional seat,"[6] but lost to incumbent Republican Eli Crane in the general election.

[5] Early in his career, Nez served as vice president of the Navajo Nation's Shonto chapter.

[12] Nez was selected as one of seventeen speakers to jointly deliver the keynote address at the 2020 Democratic National Convention.

[14] On October 16, 2023, Nez announced his candidacy for Arizona's 2nd congressional district, currently held by Republican Eli Crane.