[2] Panzo made his first team debut for Monaco on 19 December 2018, playing the full ninety minutes in 1–0 win over Lorient in the Coupe de la Ligue.

[10] On 31 January 2022, it was announced that Panzo had signed with Nottingham Forest of the EFL Championship managed by his former England U-17 coach Steve Cooper.

[16] On 30 January 2024, he was loaned to Belgian Pro League side Standard Liège until the end of the season.

[17] On 17 July 2024, he moved on a season-long loan to Primeira Liga club Rio Ave.[18][19] Panzo was part of the England U17 team which finished as runners-up to Spain in the 2017 UEFA European Under-17 Championship.

[24] On 30 August 2019, Panzo was included in the England U21 squad for the first time[25] and made his debut during the 3–2 2021 U21 Euro qualifying win against Turkey on 6 September 2019.