Griffin got his chance to make his AFL debut in the early rounds of 2007 due to the departure of Matthew Clarke and injuries to Rhett Biglands and Ivan Maric.

Griffin started well in the 2008 AFL season, with strong performances against very good ruck opponents in Will Minson and Ben Hudson, of the Western Bulldogs, Dean Cox and Mark Seaby of the West Coast Eagles and Dean Brogan and Brendon Lade of Port Adelaide.

[5] Since returning to his home state of Western Australia, Griffin has been used mainly as Fremantle's backup ruckman, competing with Zac Clarke and Aaron Sandilands for the ruck positions.

Griffin played his first game for the Dockers in round 10 of the 2011 AFL season against St Kilda, after Sandilands was unavailable due to injury.

A career-best performance against Gold Coast in round 15 saw him collect 26 disposals, 9 marks, 30 hit outs and 2 goals.