[3][4] DeLuca made his professional debut with the rookie-level Arizona League Dodgers in 2019, where he hit .273 in 26 games.

[12] His first major league hit was a single to center field off of Ranger Suárez of the Philadelphia Phillies on June 9.

[13] On July 4, 2023, DeLuca hit his first MLB home run off Ángel Perdomo of the Pittsburgh Pirates.

[14] He played in a total of 24 games in the majors, hitting .262 with two homers and six RBIs before being optioned back to the minors.

[5] On December 16, 2023, the Dodgers traded DeLuca and Ryan Pepiot to the Tampa Bay Rays in exchange for Tyler Glasnow and Manuel Margot.