During the 2011 OHL Playoffs, Binnington led the Attack past the London Knights, the Plymouth Whalers, and the Windsor Spitfires to end up in the J. Ross Robertson Cup final versus the Mississauga St. Michael's Majors.

On November 26, 2014, Binnington was called up from the Kalamazoo Wings of the East Coast Hockey League, under emergency conditions, following the injury to Blues goaltender Brian Elliott.

[6] On January 14, 2016, he made his in-game debut against the Carolina Hurricanes, coming in to relieve starter Elliott in a 4–1 loss.

[8] With the Blues playing the 2017–18 season without an AHL affiliate, Binnington was reassigned on loan to the Providence Bruins on October 9, 2017.

[11] Binnington was assigned to the St. Louis Blues AHL affiliate, the San Antonio Rampage, to begin the 2018–19 season.

[15] On February 11, Binnington was named the NHL First Star of the Week after going 3–0–0 to help the Blues to win six straight games and move into a Western Conference wild card spot.

[17] On April 4, 2019, a 7–3 victory over the Philadelphia Flyers gave Binnington his 23rd win of the season, a record for a Blues rookie goaltender.

[18] On April 10, Binnington played his first NHL playoff game, stopping 25 of 26 shots against the Winnipeg Jets in a 2–1 victory.

[20] After knocking out Winnipeg in six games, the Blues defeated the Dallas Stars in a seven-game conference semi-final series.

[22] The Blues defeated the Sharks in six games to advance to the 2019 Stanley Cup Finals where they met the Boston Bruins, the Eastern Conference champions.

[31] With Husso a free agent at the end of the season and Binnington's lengthy and expensive contract on the books, this generated speculation about the future of team goaltending.

[32] The Blues qualified for the 2022 Stanley Cup playoffs, entering the first round as underdogs against the Minnesota Wild, with Husso starting in net.

[39] On December 12, 2022, Binnington won his 100th game in a 1–0 shutout against the Nashville Predators, making him the sixth goaltender in franchise history to earn 100 victories with the club.

[45] Following the conclusion of the 2023–24 NHL regular season, with the Blues not qualifying for the 2024 Stanley Cup playoffs, Binnington accepted an invitation to make his senior national team debut at the 2024 IIHF World Championship.

[48] In 2020, Binnington posted on Instagram following the death of George Floyd, along with fellow Blues players Ryan O'Reilly and Marco Scandella.

A Reddit thread from the time of the post indicates that the caption included the tag #blacklivesmatter, in direct support of the Black Lives Matter movement.