[3] After graduating from high school, with a Frederick W. Heyl and Elsie L. Heyl Science Scholarship Fund[5][6] full-tuition scholarship from Kalamazoo College, in 1997,[3] Klepper double-majored in math and theater at Kalamazoo College and received his degree in 2001.

[2][11] He received consistently positive reviews for his segments on the show,[13] and filled in as the host in October 2016 when Trevor Noah was sick.

[14] A special titled Jordan Klepper Solves Guns premiered on Comedy Central on June 11, 2017.

[20] Klepper has said that his comedy influences include Trevor Noah,[21] Stephen Colbert,[22] and Jon Stewart.

The two met as members of The Second City and Upright Citizens Brigade and later wrote, directed, produced, and starred in short films.