Ta'amu has been a member of several National Football League (NFL) teams and has started for the St. Louis BattleHawks and Defenders of the XFL and Tampa Bay Bandits of the United States Football League (USFL).

Ta'amu played at New Mexico Military Institute for two seasons, passing for 3,014 yards and 32 touchdowns as a sophomore.

[5] With Patterson transferring to the University of Michigan, Ta'amu entered the 2018 season as the starting quarterback.

[5] He finished the season ranked second in SEC passing yards, behind Alabama's Tua Tagovailoa, who played in three more games.

[11] On October 15, 2019, Ta'amu was allocated to the St. Louis BattleHawks of the XFL, the first player for the team.

[13] He had another productive game in Week 2 against the Houston Roughnecks, with 316 combined yards of offense and four total touchdowns, but threw 2 interceptions as the Battlehawks lost 24–28.

[14] After the XFL's season was cut short, Ta'amu was placed on the reserve/other league list on April 2, 2020, in order to sign with the Kansas City Chiefs.

[28] On December 15, 2021, Ta'amu was signed to the Washington Football Team's practice squad,[29] but was released eight days later.

During this time, the starting quarterback for Washington was Taylor Heinicke, who was Ta'amu's back up in the XFL.

Ta'amu was selected with the second pick of the 2022 USFL draft by the Tampa Bay Bandits.