Mollà made his Hollywood debut in the 2001 biographical crime film Blow, where he played a villainous drug trafficker based on Carlos Lehder.

Mollà subsequently played a similar character in Michael Bay's 2003 action sequel Bad Boys II, opposite Will Smith and Martin Lawrence.

His co-star Gabrielle Union labeled him as "The Tom Cruise of Spain," when praising his performance as drug lord Johnny Tapia.

Mollà then starred in The Tulse Luper Suitcases, an ambitious multi-year, multi-media project created by avant-garde director Peter Greenaway.

He has subsequently starred in many high-profile feature films, including Elizabeth: The Golden Age, Knight and Day, Che: Part 2, Colombiana, Riddick, In the Heart of the Sea, and The Man Who Killed Don Quixote.