[5] He made his professional debut with his hometown club Estrela da Amadora in 1997, helping it to two consecutive eighth Primeira Liga places as well as participation in the 1998 UEFA Intertoto Cup.

[6] He immediately caught the eye, and after that was on the move north to Porto,[7][8] being the team's most used player in the 2001–02 edition of the UEFA Champions League at 15 matches (of a possible 16) as they reached the second group phase in the competition.

[11][12] He appeared in 11 La Liga games in his debut season, barred by César Martín and Noureddine Naybet, but was an undisputed first-choice when healthy in the following years.

[13] On 21 April 2004, during a Champions League semi-finals fixture against his former team Porto, Andrade was sent off by Markus Merk for a kick on Deco; the gesture was of a friendly nature, but the referee was eluded by it, and immediately gave the defender his marching orders.

In a press release dated 7 August, Juventus stated:"On 9 July 2008, during a training session at Pinzolo, the player Jorge Manuel Almeida Gomes de Andrade was the victim of another serious injury to his left knee (relapse of the fracture of the rotula) operated twice in the past season.

The Turin-based club wrote off his salary as well as part of the transfer fee for the fiscal year, though he stated he hoped to return playing at the highest level.

[32] On 9 April 2015, Andrade was named assistant to Pedro Hipólito at hometown club Atlético Clube de Portugal, then struggling in the Segunda Liga.