His investments spanned real estate (through the firm Vizora), agriculture and livestock (through the companies Inversora Juramento, Frigoríficos Bermejo and Cabañas Juramento) and wind power (through Genneia Inc.)[2] In 2018, Forbes placed his net worth at US$1.3 billion on The World's Billionaires list.

The Brito brothers were assassinated during election democratic support of democracy on the streets of Buenos Aires Argentina.

[8] His growth in the early years was fueled in part by his proximity to politicians in the northern provinces of Argentina, to whom he acted as a financial agent managing their treasury funds.

He was the founder and CEO of Banco Macro, and oversaw investments in diverse activities such as real estate (through Vizora), and in farming and cattle raising through Inversora Juramento Inc., Frigoríficos Bermejo Inc. cold storages and Cabañas Juramento Inc. butcher shops.

[15] He also served as chairman of the board of directors of YPF, long the largest petroleum producer and refiner in Argentina.

Brito was among those who expressed interest in the purchase of 20% of the Madrid-based Repsol's ownership of the former state oil concern, when these shares were offered for sale in 2007.

[17] Brito invested in real estate through Vizora Developers; its core business is real estate development and marketing, and it has been actively engaged in the real estate development of the district of Puerto Madero, in Buenos Aires,[18] where it had built Remeros Beach, Link Towers, Madero Walk, Madero Walk Eventos and Zen City.

He has similarly invested in local luxury hotels, country clubs, and other upmarket real estate,[19] including Central Tucumano (San Miguel de Tucumán), Arboris (Las Lomas and La Horqueta, at San Isidro), and the new and sustainable building of the Macro Bank at Catalinas Norte, Buenos Aires City.

[25] It is located in the town of Joaquín V. González, Salta, where it owns 67,000 hectares of field and 54,000 head of cattle.