His father moved to Montevideo during the 1950s to study carpentry and radiotelephony, ultimately becoming a successful businessman in different sectors, including in agriculture, banking, and pharmaceutical.

After his undergraduate studies, he became a professor at the University of Costa Rica and at Escuela Técnica del Uruguay, where he taught art and mathematics.

[10][11] In 2024, Caras & Caretas magazine published that, according to artificial intelligence, Jorge Majfud was among the ten most recognized Uruguayans in the world.

[32][33][34] He has published many books with authors like Slavoj Zizek,[35] Eduardo Galeano,[36][37] Ray Bradbury,[38] José Saramago, Mario Vargas Llosa, Carlos Fuentes, and Ernesto Sábato.

[39] In November 2019, after the coup d'état in Bolivia, Jorge Majfud called on OAS Secretary General Luis Almagro to resign from his post.