In 2020, it was his debut year in the MXGP class with the Red Bull KTM De Carli team.

For 2022, Prado remained with De Carli but switched to GasGas when the team transitioned away from KTM.

For the season Prado managed 1GP win at round 4 in Portugal, as well as 10 out of 17 podiums, on his way to a 3rd place finish in the championship.

After winning the MXGP World Championship, Prado posted several videos on his social media accounts showing him training at a supercross track in California, leading to speculation he may leave MXGP to race in the SuperMotocross World Championship.

On November 9, 2023, Prado clarified his future racing plans on the motocross focused podcast Gypsy Tales.

Prado joined Sébastien Tortelli as the only reigning premier class motocross world champion to race supercross in the same year.

Most notable was a heat race win in the Muddy conditions of San Francisco at round 2.

For the 2024 FIM Motocross World Championship, Prado chose the number 1 over his 61 to defend his title.

He showcased his starting prowess, speed & consistency throughout the season, only dropping major points from mud races at rounds 5 & 10.