Jorge Santini Padilla (born March 11, 1960) is a Puerto Rican politician who previously served as the mayor of San Juan.

At present, he is lieutenant colonel in the Puerto Rico State Guard, assigned to the Judge Advocate General's Corps.

On September 18, 2002, President George W. Bush appointed Mayor Santini to serve on the National Infrastructure Advisory Council.

Santini became a partner at the law firm of Miranda Cárdenas & Córdova where he specialized in medical malpractice suits.

Santini entered the race for Mayor of San Juan in 1999 and challenged Senate President Charlie Rodriguez in a PNP primary.

[11] In 2020 the office of ethics sued Santini for income he earned working for the Senate and the National Guard simultaneously.