Historically a member of the Justicialist Party, Sarghini has served in a number of political posts throughout his career, most notably as a member and president of the Buenos Aires Province Chamber of Deputies, as Minister of Economy of Buenos Aires Province during the successive administrations of Eduardo Duhalde and Carlos Ruckauf, and briefly as Secretary of Communications during Duhalde's interim presidency in 2002.

[1] Sarghini was appointed Undersecretary of Finances of Buenos Aires Province in 1989, in the administration of economy minister Jorge Remes Lenicov during the governorship of Antonio Cafiero.

[3] In March 2002, Sarghini was appointed Secretary of Communications of Argentina by then-interim president Duhalde, taking over from Oscar Félix González.

[6] On 15 December 2003, Sarghini was appointed President of the Bank of Buenos Aires Province (Banco Provincia), and served in the position until 15 July 2005, when he resigned to run for a seat in the Argentine Chamber of Deputies.

[14] In 2013, Sarghini was elected to the Buenos Aires Province Chamber of Deputies as part of the Renewal Front list in the Capital Electoral District, which encompasses the Greater La Plata.