Jorge de Cárdenas y Manrique de Lara (April 23, 1584 – October 30, 1644), 4th Duke of Maqueda and 6th Duke of Nájera, was a Spanish noble, military and statesman, born in Elche.
He was the son of Bernardino de Cárdenas y Portugal, 3rd Duke of Maqueda, 2nd Marquis of Elche, and of Luisa Manrique de Lara, 5th Duchess of Nájera.
Then he was made Captain General of the Armada and member of the State Council by King Philip IV of Spain.
In November 1641, he was chosen to lead a squadron from Cadiz to intercept a Dutch fleet, but his command was disputed by the Governor of that city Juan Alonso Idiáquez, 2nd Duke of Ciudad Real.
Idiaquez took command of the fleet and won the Battle of Cape St. Vincent (1641).