José Ascanio

In 2005, he played in 5 games for the Myrtle Beach Pelicans, recording 3 wins, 1 loss, a 6.10 ERA, and a career-low 12 K, before being sidelined with a fractured back injury.

On July 13, 2007, Ascanio was called up by the Braves after Wilfredo Ledezma had trouble getting back to the U.S. after going home to Venezuela during the All-Star break.

On December 4, 2007, Ascanio was traded to the Chicago Cubs for reliever Will Ohman and infielder Omar Infante.

On May 10, 2009, Ascanio was called up by the Cubs from Triple-A Iowa after possessing a 1.01 ERA in 262⁄3 innings pitched as a starter.

On July 30, 2009, Ascanio was traded to the Pittsburgh Pirates with Kevin Hart and Josh Harrison for John Grabow and Tom Gorzelanny.

Ascanio was assigned to the Diablos Rojos del México in 2013, and was later signed by the Petroleros de Minatitlán.

On January 8, 2018, it was announced that Ascanio would return to the Mexican League with the Tecolotes de los Dos Laredos.