José Eusebio Colombres (16 December 1778 – 11 February 1859) was an Argentine statesman and bishop.
After independence, he participated in the League of the North and consequently had to live in exile in Livi-Livi close to Tupiza, Bolivia, until the fall of Juan Manuel de Rosas.
In 1858 Colombres was appointed Bishop of Salta on the suggestion of Justo José de Urquiza but died less than two months later before being consecrated.
Although sugar cane had been brought to northern Argentina by the Jesuits, Colombres started growing it on his land in 1821 and introduced the techniques to make its cultivation an industry and income generator, with the first mill.
His house in Tucumán, around which the city's extensive Ninth of July Park was developed in 1910, is now the Museum of the Sugar Industry and a National Historic Monument.