José Eugenio De León Domenech (born August 7, 1992) is a Puerto Rican professional baseball pitcher who is a free agent.

He has previously played in Major League Baseball (MLB) for the Los Angeles Dodgers, Tampa Bay Rays, Cincinnati Reds, and Minnesota Twins.

[18] He opened the season on the minor league disabled list due to discomfort in the flexor mass muscle in the forearm, which is often a precursor to Tommy John surgery.

[19] On May 29, De León got his first call-up by the Rays due to a depleted bullpen from a 15 inning victory against the Minnesota Twins the day before.

[22] One week later, Dr. James Andrews successfully performed Tommy John surgery, ending De León's 2018 season.

[29] De León made two appearances for the rookie-level Florida Complex League Red Sox, allowing two runs on theee hits with four strikeouts in two innings pitched.

[30] On November 29, 2021, De León signed a minor league contract with the Toronto Blue Jays organization, and received an invitation to spring training.

[33] He began the 2023 season with the Triple-A St. Paul Saints, where he made 9 appearances and recorded a 3.62 ERA with 26 strikeouts and 1 save in 27.1 innings pitched.

On June 26, it was announced that De León would undergo Tommy John surgery after an MRI revealed a torn ligament in his right elbow.

On March 13, 2023, he started versus Israel and retired every batter faced over 5+2⁄3 innings, including a WBC-record 10 strikeouts, to exit with an ongoing perfect game.

Yacksel Ríos, Edwin Díaz, and Duane Underwood Jr. each relieved De León and retired every batter faced, and Martín Maldonado caught on the way to a 10–0 win.

The contest ended when Maldonado scored on a walk-off hit in the bottom of the eighth inning that invoked the tournament's mercy rule.