Starting his career with Levante, José Enrique was signed by their rivals Valencia and made La Liga appearances for Celta Vigo and Villarreal.

[citation needed] On 6 August 2007, José Enrique signed for English Premier League club Newcastle United for a fee believed to be £6.3 million.

[citation needed] José Enrique's performances were rewarded when he was made the official Newcastle United Player of the Season for 2009–10, voted for by the fans.

He also achieved the accolade of being named in the PFA Team of the Year alongside Newcastle teammates Fabricio Coloccini, Kevin Nolan and Andy Carroll.

[9] On 1 April, he was forced to play as a goalkeeper for the remaining 13 minutes of the match against his old club Newcastle after Pepe Reina was sent off for headbutting James Perch.

[11] On 17 November 2012, in a league match against Wigan Athletic, José Enrique scored his first goal for Liverpool in the 65th minute, having been increasingly reinvented as a left wing-back in a 3–5–2 formation under manager Brendan Rodgers.

[17] He made his debut on 8 October, playing the full 90 minutes of a 2–1 loss away to Sevilla Atlético, and scored his first goal on 5 November in a 2–2 draw away to RCD Mallorca.