José Manuel Espada (born February 22, 1997) is a Puerto Rican professional baseball pitcher in the San Diego Padres organization.

[1] He made his professional debut with the rookie–level Gulf Coast League Blue Jays, posting a 3.41 ERA in 10 games (7 starts).

[2] In 2016, Espada made 12 appearances (10 starts) for the rookie–level Bluefield Blue Jays, recording a 4.92 ERA with 32 strikeouts across 53.0 innings of work.

On September 2, Espada, Jeremy Wu-Yelland, Oddanier Mosqueda, and Jake Wallace pitched a combined no-hitter against the Asheville Tourists.

[13] In 2023, Espada appeared in 38 games for the Double–A San Antonio Missions and Triple–A El Paso Chihuahuas, accumulating a 2.81 ERA and 110 strikeouts in 83+1⁄3 innings pitched.