José Guadalupe Osuna Millán (born December 10, 1955) is a Mexican economist and politician member of the National Action Party (PAN) who served as Governor of Baja California.

He has served as municipal president of Tijuana (1995—1998) and as the Director of the State Commission of Water.

In 2003, he was elected as Federal Representative in the LIX Legislature of the Mexican Congress for the V Electoral District of Baja California.

Osuna won the election defeating the PRI candidate Jorge Hank.

Currently he is leading an effort to crack down on the drug cartels and corruption within the state government.