He is best known as the pioneering practitioner of the art form known as Letras y figuras, in which the letters of a patron's name is composed primarily by contoured arrangements of human figures surrounded by vignettes of scenes in Manila - an art form that may have derived loosely from illuminated manuscripts.
[4] Santiago Pilar, an authority on 19th-century paintings, described Lozano's works as "some of the most quaint and endlessly fascinating relics of Filipino culture in Spanish times".
A local commentator, Rafael Diaz Arenas, remarked as early as 1850 that Lozano was "a watercolourist without rival".
Lozano also painted in the conventional costumbrista tradition as a means of supplying the demand for souvenirs of Manila to foreign visitors.
A folio of Lozano's watercolors surfaced in a 1995 episode of Antiques Roadshow (the UK edition) with appraiser Peter Nahum.