[3] From 1923 to 1924, he participated in the Veterans' And Patriots' Movement led by Carlos García Vélez in opposition to the Alfredo Zayas y Alfonso administration.

For rejecting the presidency of a Gerardo Machado electoral district, he was imprisoned for two years in Castillo del Príncipe on the Isle of Pines.

[7] During this period, Sumner Welles reported that Irisarri was a law partner of Cuban President Mario García Menocal's son-in-law, Eugenio Sardina.

[8] In September 1933, Irisarri was a part of the brief provisional government of Cuba, known as the Pentarchy of 1933, which included Porfirio Franca, Guillermo Portela, Ramón Grau, and Sergio Carbó.

[16][17] After Fulgencio Batista's 1952 Cuban coup d'état deposed President Carlos Prío Socarrás, Irisarri immediately resigned from the position he held.