Izquierdo would subsequently abandon football for several years following his brother's death in a traffic accident, before eventually returning to join Deportivo Pereira.

[20] He scored another spectacular goal against West Ham on 3 February 2018, producing a moment of quality, curling it over everyone from the corner edge of the penalty area putting the Seagulls 2–1 ahead in an eventual 3–1 victory.

[21] On 1 January 2018, Izquierdo provided two assists in Brighton's 2–2 home draw against AFC Bournemouth, winning the Man of the Match award.

[24] He made his return to the senior matchday squad on 31 January 2021 in a home fixture against Tottenham Hotspur in which he remained an unused substitute in the 1–0 win.

[25] Izquierdo made his first appearance for the first team in two–and–a–half years, returning from his injuries, coming on as a substitute in the 82nd minute for Leandro Trossard in the 1–0 away loss to already relegated Sheffield United on 24 April 2021.

[26] Speaking to The Argus during the week after his return to action, Izquierdo admitted that whilst injured he feared his career was over being told, "that there was the possibility of not playing again."

With his injury-hit spell at the Seagulls lasting four seasons, he made 54 appearances, scoring five times and helping the club establish itself in the Premier League.