Nicknamed Caldera, he is remembered for a 48-metre goal he scored against Boca Juniors in 1999 and for his hat-trick against Estudiantes' derby rivals Gimnasia y Esgrima La Plata on 15 October 2006.

He explained that his decision came after coach Alejandro Sabella informed him that he was not being considered for the 2009 FIFA Club World Cup.

[3] On 4 January 2010, Calderón announced that Argentinos Juniors coach Claudio Borghi convinced him to return to football, after a brief retirement from the game.

In an article, Calderón stated, "El Bichi (Borghi) has given me the chance to retire from within a football field".

After winning the 2010 Clausura, Calderón played one last professional game with his first team, Defensores de Cambaceres, in which he scored one last goal from a penalty kick.