José Manuel García-Margallo y Marfil (pronounced [xosemaˈnwel ɣaɾˈθi.a maɾˈɣaʎo]; born 13 August 1944) is a Spanish politician who served as Minister of Foreign Affairs and Cooperation from 2011 to 2016.

On 22 December 2011, Margallo was inaugurated as Minister of Foreign Affairs and Cooperation in the first cabinet presided by Mariano Rajoy.

[5] In March 2012, Margallo announced that, in response to savage killings and human rights abuses in Syria, his country would cease activities at its embassy in Damascus, but would not formally close its mission.

[9] A day after sanctions against Iran were lifted in January 2016, Margallo entered into negotiations with the Iranian government over the construction of an Iranian-owned oil refinery at the Gibraltar strait.

[10] Almost 50 years after coming close to possibly provoking a nuclear disaster, Margallo and his counterpart John Kerry of the United States agreed in 2015 to remove contaminated soil from an area in southern Spain where an American warplane accidentally dropped hydrogen bombs.

The deal, announced on a visit by Kerry to Spain, followed years of wrangling between the two countries over how to clean up the area around the seaside village of Palomares, over which the accident took place in 1966.

[16] In addition to his committee assignments, Margallo is part of the European Parliament Intergroup on Seas, Rivers, Islands and Coastal Areas.

[19] Under Margallo's leadership, the Foreign Ministry on 11 July 2016 summoned Britain's ambassador following what it said were "reckless" moves by a Royal Gibraltar Police patrol boat.