By then he is clearly identified with the political group of Sonoran generals turned politicians, Álvaro Obregón and Plutarco Elías Calles.
During the interim presidency of Emilio Portes Gil (1928-1930), he served as Head of the Department of the Federal District (1929–30), the jurisdiction of the national capital.
Following the election of Pascual Ortiz Rubio as president, he appointed Puig Casauranc as Secretary of Education (1930–31) for a second term, and then Mexican Ambassador to the United States (1931–33).
After Ortiz Rubio's resignation, President Abelardo L. Rodríguez appointed him Secretary of Foreign Affairs (1933–34).He was outspoken in this position.
The "apogee of his public career was his confrontation with U.S. Secretary of State, Cordell Hull, at the 1933 Pan-American Conference in Montevideo, Uruguay... critici[zing] international bankers and U.S. dominance in the Mexican economy.