Born in Valencia on 9 October 1968,[1][2] Rodríguez Uribes earned a licentiate degree in law at the University of Valencia (UV); he later obtained a PhD in the same field at the Charles III University of Madrid (UC3M),[3] reading a dissertation in 1998 titled Los discursos democrático y liberal sobre la opinión pública (dos modelos, Rousseau y Constant) and supervised by Gregorio Peces Barba.

Rodríguez Uribes joined the Federal Executive Board of the Spanish Socialist Workers' Party (PSOE) led by Pedro Sánchez in June 2017, tasked in the area of Laicity.

[7] Following the investiture of Sánchez as prime minister in June 2018, Rodríguez Uribes was chosen to replace Concepción Dancausa at the helm of the Government Delegation in the Community of Madrid.

[10] Rodríguez Uribes remained in office until April 2019 as he was included then in the 3rd place of the PSOE list for the 2019 Madrilenian regional election led by Ángel Gabilondo.

[14][15] Amid the COVID-19 pandemic in Spain, Rodríguez Uribes led efforts to re-open the country's public life by announcing in May 2021 that a maximum of 5,000 spectators would be able to attend soccer games in regions with fewer than 50 COVID-19 cases per 100,000 inhabitants.