He attended high school and college in the city of Mérida at the Universidad de Los Andes (ULA), graduating with a Philosophy and Arts specialty in 1914.

He later fought against the dictatorship of Marco Pérez Jiménez, being one of the signatories to the Manifiesto de los Intelectuales (the Intellectuals' Manifesto), which outlined strategies on the road to overthrow the dictator.

As Venezuela's ambassador to Cuba, Nucete Sardi broke relations with the dictatorship of Fulgencio Batista after President Carlos Prío Socarrás was ousted.

Relations were again broken in 1961 after a tense and deteriorating with the growing concentration of power around Fidel Castro as Primer Minister overshadowed the Presidency of Manuel Urrutia Lleó.

As a lecturer he promoted a vast amount of work on the history and literature of Venezuela throughout New York City, Paris, Brussels, Buenos Aires, Rio de Janeiro, Havana, Tel-Aviv, La Plata and London.