José Luis Paniagua Sánchez (born August 20, 1973) is a Dominican former professional baseball relief pitcher.

He appeared in Major League Baseball from 1996 through 2003 with the Montreal Expos, Seattle Mariners, Detroit Tigers, and Chicago White Sox from 1996 to 2003.

[4] Paniagua made his Major League Baseball (MLB) debut on April 5, 1996, defeating the Cincinnati Reds, as the Expos needed a starter to replace the injured Carlos Pérez.

[11] Paniagua spent most of the 1998 season with the Tacoma Rainiers, the Mariners' Class AAA affiliate, which play in the Pacific Coast League.

[12][13] On December 16, 2001, the Mariners traded Paniagua with Brian Fuentes and Denny Stark to the Colorado Rockies for Jeff Cirillo.

He played for the Rojos del Águila de Veracruz in the Mexican League, until the Chicago White Sox purchased him on August 26, 2003.